What is cancer LBH589?
- cancer lbh
Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
- Evidently, a method of inhibiting growth of cancer cells, comprising contacting the cancer cells with a composition comprising a therapeutically effective amount for inhibiting cancer cell growth of at least one selected from the group consisting of an LBH inhibitor, a WNT7a protein, and a nucleic acid encoding WNT7a protein, under conditions such that the cancer cells die or differentiate. Protein is a molecule made up of amino acids. Proteins are needed for the body to function properly. They are the basis of body structures, such as skin and hair, and of other substances such as enzymes, cytokines, and antibodies. Acid is a chemical that gives off hydrogen ions in water and forms salts by combining with certain metals. Acids have a sour taste and turn certain dyes red. Some acids made by the body, such as gastric acid, can help organs work the way they should. An example of an acid is hydrochloric acid. Acidity is measured on a scale called the pH scale. On this scale, a value of 7 is neutral, and a pH value of less than 7 to 0 shows increasing acidity.
- It appears that, compositions described herein for inhibiting cancer cell growth include a therapeutically effective amount of an inhibitor of LBH for inhibiting cancer (e.g., estrogen receptor negative basal-type breast cancer) cell growth and a pharmaceutically acceptable carrier. Any suitable inhibitor of LBH activity or expression can be used. Receptor is a molecule inside or on the surface of a cell that binds to a specific substance and causes a specific effect in the cell. Estrogen receptor negative, describes cells that do not have a protein to which the hormone estrogen will bind. Cancer cells that are estrogen receptor negative do not need estrogen to grow, and usually do not stop growing when treated with hormones that block estrogen from binding. Also called ER-. Estrogen is a type of hormone made by the body that helps develop and maintain female sex characteristics and the growth of long bones. Estrogens can also be made in the laboratory. They may be used as a type of birth control and to treat symptoms of menopause, menstrual disorders, osteoporosis, and other conditions. Estrogen receptor is a protein found inside the cells of the female reproductive tissue, some other types of tissue, and some cancer cells. The hormone estrogen will bind to the receptors inside the cells and may cause the cells to grow. Also called ER. Breast, glandular organ located on the chest. The breast is made up of connective tissue, fat, and breast tissue that contains the glands that can make milk. Also called mammary gland. Breast cancer, cancer that forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). It occurs in both men and women, although male breast cancer is rare.
- It might seem apparant that, like in breast cancer, LBH expression positively correlates with expression of a subset of Wnt target genes including TCF4, SFRP1, and DKK3. The Pearson correlation coefficients are shown to the right.
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